1. Pathogenesis

The pathogenesis of this disease is due to infection with coccidia and bacteria, which causes inflammation of the small intestinal mucosa, resulting in swelling, thickening, and bleeding of the intestinal wall, which in turn causes a large number of mucosal epithelial cells to disintegrate, fall off, and necrosis. On the other hand, the proliferation of pathogens such as coccidia can cause intestinal inflammation, causing the disintegration and shedding of mucous epithelial cells, and at the same time It also consumes nutrients and creates a subcutaneous anaerobic environment, which accelerates the infection of anaerobic bacteria such as Clostridium welchii that enter the feed, enhances the reproductive capacity, and produces a large amount of exotoxin, which further causes intestinal damage and causes poisoning: In addition, toxin production increases due to secondary infection of intestinal bacteria and viruses such as Escherichia coli.

The clinical manifestations

The disease is more common in broilers of 30-40 days of age. Other days can also occur, but to a lesser extent. The disease is prone to occur simultaneously or sequentially with coccidiosis infection. The main clinical symptoms are:

In the early stage of the disease, chickens generally have no obvious symptoms, normal spirit, normal appetite, and the mortality rate is also within the normal range. If you observe carefully, you will find that the feces of individual chickens become thin and shapeless, and the feces contain undigested feed. It is thinner, not formed, not piled up, and occupies a larger area than normal chicken manure. There are more undigested corn grits and soybean meal grits in the feces. The color of the feces becomes lighter, slightly pale or light yellow-green. , When most of the chickens in the flock appear this kind of feces about 2-3 days, the feed intake of the chickens begins to decrease, generally by about 10% to 30%, and some chickens can reduce the feed intake by more than 40%. If it is not properly and timely treated, it will lead to greater losses. In the middle and late stages of the disease, individual chickens will have nervous excitement, run wildly, and then succumb to death.

Three, autopsy symptoms

In the early stage of the disease, the duodenum and the jejunum before the yolk pedicle thicken, become lighter in color, and appear gray-white, like a thick layer of bran, which can be easily peeled off; while the intestinal mucosa is thickened, the intestinal The walls are also thickened. The intestinal lumen is empty, with few contents, and some have no contents in the intestinal lumen; some contents are undigested feeders. When the disease develops to the middle and late stages, the intestinal wall becomes thin, the mucosa falls off, and the intestinal contents are egg white-like. , Mucus-like, individual flocks are particularly serious, the intestinal mucosa is almost completely detached and disintegrated, the intestinal wall is thinned, and the intestinal contents are blood-colored egg white-like or mucus-like, persimmon-like.

4. Preventive measures

Coccidiosis is mostly the "fuse" of enterotoxic syndrome, so there is a saying in the industry that "if you don't treat the intestines properly, you will be busy in vain". Therefore, preventing the occurrence of coccidiosis is the top priority of preventing enterotoxic syndrome. Cutting off the life chain of coccidia in vitro, such as keeping the house ventilated, dry and proper stocking density, timely removal of feces, regular disinfection, etc., can effectively prevent the occurrence of this disease.

V. Treatment measures

The first priority in the treatment of enterotoxic syndrome is to treat coccidiosis, and sulfa drugs are the correct choice. The treatment with diclazuril and toltrazuril is often ineffective. In addition, Pulsatilla Oral Liquid has significant effects of clearing heat and detoxifying, drying dampness and cooling blood. Therefore, it has a good curative effect on pullorum caused by Salmonella and enteritis and diarrhea caused by Escherichia coli. Astragalus can not only consolidate the body, but also has a good effect on the intestines.

1. Mild enterotoxic syndrome, mild coccidiosis infection

Xiyankang (150kg water/bag) + coccidiosis drug (Tianyuanqiuning 100kg water/bottle), used for 3 days.

2. Severe enterotoxic syndrome, coccidial infection is more serious

Xiyankang (150kg water/bag) + coccidiosis drug (Tianyuanqiuning 100kg water/bottle) + Pulsatilla officinalis powder (1-2g/chicken) for 3 days, after treatment, use probiotics for 5 days . Conditioning the intestines, repairing the intestinal mucosa, speeding up recovery and preventing recurrence.